Publications

ALL WANG PUBLICATIONS

2026

Enforced ZFP281 expression delays breast cancer initiation and can provide lifelong protection against breast cancer metastasis

Singh, D.K., Zhou, H., Sherpa, N., Zheng, X.Y., Lomakin, A., Razghandi, P., Huang, X., Kadamb, R., Shukla, S., Salazar, L.V., Entenberg, D., Zheng, D., Curtis, C., Wang, J.*, Aguirre-Ghiso, J.A.* (Corresponding authors)
NC cover

WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity

Wang, D., Shi, X., Xie, J. Zhao, L., Wu, B., Dong, Q., Huang, Y., Suo, J., Wang, X., He, B., Yan, S., Xue, H., Shi, Y., Liu, Y.*, Wang, J.*, Chen, Y.*, and Li, Y.*

2025

Expert Opinion on Therapeutic Targets journal cover

Paraspeckle component 1 in acute myeloid leukemia: prospects for therapeutic targeting

Xu, M. and Wang, J.*
Editorial Overview

Editorial overview: 3Rs update: a new era in cellular identity and therapeutic plasticity

Peng Du and Jianlong Wang*
iScience Cover

Multomics reveal biomolecular shifts and ER stress in sleep-restricted women affecting NSC functions

Malik, V., Huang, X., Zhou, H., Bojar, R., Soni, R.K., Landry, D.W., Jelic, S., and Wang, J.*
COGEDEV generic cover

Totipotency or plenipotency: rethinking stem cell bipotentiality

Wen, D.* and Wang, J.*
Nat Comm generic cover

Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation

Vann, K.R., Sharma, R., Hsu, C.-C., Devoucoux, M., Tencer, A.H., Zeng, L., Lin, K., Zhu, L., Li, Q., Lachance, C., Ospina, R.R., Tong, Q., Cheung, K.L., Yang, S., Biswas, S., Xuan, H., Gatchalian, J., Alamillo, L., Wang, J., Jang, S.M., Klein, B.J.
Lu, Y., Ernst, P., Strahl, B.D., Rothbart, S.B., Walsh, M.J., Cleary, M.L., Cote, J., Shi, X., Zhou, M.-M.
PSPC1 CSC Journal Cover

PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1

Hong, J. Sui, P., Li, Y., Xu, K.Y., Lee, J.-H., Wang, J., Chen, S., Zhang, P., Wingate, N., Noor, A., Yuan, Y., Hromas, R., Zhou, H., Hamamoto, K., Su, R., Yin, C.C., Ye, F., Quesada, A.E., Chen, J., Huang, S., Zhou, D., You, M.J., Yang, F.-C.*
Wang, J.*, and Xu, M*.
Nat Comm Generic Cover

Pluripotency factor Tex10 finetunes Wnt signaling for spermatogenesis and primordial germ cell development

Yuan, F., Yang, J., Ma, F., Hu, Z., Malik, V., Zang, R., Li, D., Shi, X., Huang, X., Zhou, H., and Wang, J.*

2024

Nat Comm

DDX18 coordinates nucleolus phase separation and chromatin organization to control the pluripotency of human embryonic stem cells

Shi, X., Li, Y., Zhou, H., Hou, X., Yang, J., Malik, V., Faiola, F., Ding, J., Bao, X., Modic, M., Zhang, W., Chen, L., Mahmood, S.R., Apostolou, E., Yang, F.-C., Xu, M., Xie, W., Huang, X., Chen, Y., and Wang, J.*
Mol Cancer

NAC1 promotes stemness and regulates myeloid-derived cell status in triple-negative breast cancer

Ngule, C., Shi, R., Ren, X., Jia, H., Oyelami, F., Li, D., Park, Y., Kim, J., Hemati, H., Zhang, Y., Xiong, X., Shinkle, A., Vanderford, N. L., Bachert, S., Zhou, B. P., Wang, J., Song, J., Liu, X., and Yang, J.-M.
Blood

Loss of stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML

Hassan, N., Yi, H., Malik, B., Gaspard-Boulinc, L., Samaraweera, S. E., Casolari, D.A., Seneviratne, J., Balachandran, A., Chew, T., Duly, A., Carter, D.R., Cheung, B.B., Norris, M., Haber, M., Kavallaris, M., Marshall
G.M., Zhang, X.D., Liu, T., Wang, J., Liebermann, D.A., D’Andrea, R.J., and Wang, J.Y.
Dev Cell

ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1

Huang, X., Balmer, S., Lyu, C., Xiang, Y., Malik, V., Wang, H., Zhang, Y., Cai, B., Xie, W., Hadjantonakis, A.-K., Zhou, H., and Wang, J.*

2023

Scientific Reports

Mild sleep restriction increases endothelial oxidative stress in female persons

Shah, R., Shah, V.K., Emin, M., Gao, S., Sampogna, R.V., Aggarwal, B., Chang, A., St-Onge, M.-P., Malik, V., Wang, J., Wei, Y., and Jelic, S. (2023)
Front. Mol. Neurosci

An intellectual-disability-associated mutation of the transcriptional regulator NAC1 impairs glutamatergic neurotransmission

Daniel, J.A., Elizarova, S., Shaib, A., Chouaib, A., Magnussen, H. M., Wang, J., Brose, N., Rhee, J.S., Tirard, M. (2023)

2022

Nature Cancer

ZFP281 drives a mesenchymal-like dormancy program in early disseminated breast cancer cells that prevents metastatic outgrowth in the lung

Nobre, A.R., Dalla, E., Yang, J., Huang, X., Wullkopf, L., Risson, E., Razghandi, P., Anton, M.L., Zheng, W., Seoane, J.A., Curtis, C., Kenigsberg, E., Wang, J., and Aguirre-Ghiso, J.A. (2022)
Oncogenesis

A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer

Kim, M., Singh, M., Lee, B.-K., Hibbs, M., Richardson, K., Ellies, L., Wintle, L., Stuart, L. M. Wang, J. Y., Voon, D. C., Blancafort, P., Wang, J., Kim, J., Leedman, P. J., and Woo, A. J. (2022)
Life Science Alliance

Comparative functional genomics identifies unique molecular features of EPSCs

Malik, V., Zang, R., Fuentes-Iglesias, A., Huang, X., Li, D., Fidalgo, M., Zhou, H., and Wang, J.*
Protein&Cell

LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells

Sun, Z., Yu, H., Zhao, J., Tan, T., Pan, H., Zhu, Y., Chen, L., Zhang, C., Zhang, L., Lei, A., Xu, Y., Bi, X., Huang, X., Gao, B., Wang, L., Correia, C., Chen, M., Sun, Q., Feng, Y., Shen, L., Wu, H., Wang, J., Shen, X., Daley, G. Q., Li, H., and Zhang, J
Trends in Genetics

Pursuing totipotency: authentic totipotent stem cells in culture

Malik, V., and Wang, J. (2022)
Science Advances

NAC1 modulates autoimmunity by suppressing regulatory T cell-mediated tolerance

Yang, J.-M.*, Ren, Y., Kumar, A., Xiong, X., Das, J.K., Peng, H.-Y., Wang, L., Ren, X., Zhang, Y., Ji, C., Cheng, Y., Zhang, L., Alaniz, R.C., de Figueiredo, P., Fang, D., Zhou, H., Liu, X., Wang, J.*, and Song, J.* (2022)
Cell Reports

A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency

Huang, X., Bashkenova, N., Hong, Y., Guallar, D., Hu, Z., Malik, V., Li, D., Shen, X., Zhou, H., and Wang, J.* (2022)
Sci Adv

eIF4A2 targets developmental potency and histone H3.3 transcripts for translational control of stem cell pluripotency

Li, D., Yang, J., Huang, X., Zhou, H., and Wang, J.*
Nat Chem Biol

Phase separation of RNA-binding protein promotes polymerase binding and transcription

Shao, W., Bi, X., Pan, Y., Gao, B., Wu, J., Yin, Y., Liu, Z., Peng, M., Zhang, W., Jiang, X., Ren, W., Xu, Y., Wu, Z., Wang, K., Zhan, G., Lu, J.Y., Han, X., Li, T., Wang, J., Li, G., Deng, H., Li, B., and Shen, X.
JGG

Zfp281 is essential for epiblast maturation through a cell-autonomous effect

Zang, R., Huang, X., Li, D., Zhou, H., Gao, S., and Wang, J.*
Nucleic Acids Res

An RNAi screen of RNA helicases identifies eIF4A3 as a regulator of embryonic stem cell identity

Li, D., Yang, J., Malik, V., Huang, Y., Huang, X., Zhou, H., and Wang, J. (2022)

2021

CSC

Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions

Wang, J., Yu, H., Ma, Q., Zeng, P., Wu, D., Hou, Y., Liu, X., Jia, L., Sun, J., Chen, Y., Guallar, D., Fidalgo, M., Chen, J., Yu, Y., Jiang, S., Li, F., Zhao, C., Huang, X., Wang, J., Li, C., Sun, Y., Zeng, X., Zhang, W., Miao, Y., and Ding, J.
NC

Oct4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human

Huang, X., Park, K., Gontarz, P., Zhang, B., Pan, J., McKenzie, Z., Fischer, L.A., Dong, C., Dietmann, S., Xing, X., Shliaha, P.V., Yang, J., Li, D., Ding, J., Lungjangwa, T., Mitalipova, M., Khan, S.A., Imsoonthornruksa, S., Jensen, N., Wang, T.,
Kadoch, C., Jaenisch, R., Wang, J.*, and Theunissen, T.W.*
P&C

Zfp281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency

Huang X., Bashkenova, N., Yang, J., Li, D., and Wang, J.*

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