Research Summary

Our lab’s research focus is to understand the gene regulatory mechanisms that drive the pathogenesis of lung cancer. We want to know: 1) Which chromatin states facilitate malignant transformation? 2) How are gene regulatory programs co-opted by tumors throughout the course of tumor evolution? 3) What genetic dependencies or targetable features arise in cancers with specific chromatin states? We study chromatin regulatory complexes and how they regulate gene expression and tumor cell biology during lung cancer evolution and in response to therapy. 

We have a particular interest in SWI/SNF chromatin remodeling complexes, which are a heterogeneous group of protein complexes that have key roles in development and disease. Genes encoding for SWI/SNF subunits are among the most frequent targets of mutation in diverse cancer types – highlighting their central role in human cancer. However, the distinct mechanisms through which specific mutations facilitate malignant transformation and support tumor evolution are still poorly understood. This reflects the complexity of SWI/SNF biology given the heterogeneity of these complexes and the diversity, cell type-specificity, and dynamic nature of their functions. We seek to understand how these complexes function in lung cancer and the mechanisms through which alterations in genes encoding for their subunits contribute to tumorigenesis.

Our group uses genetically engineered mouse models (GEMMs), organoids, and patient-derived xenografts (PDXs) as model systems. We leverage cutting-edge technologies in gene editing, chromatin profiling, transcriptomics, and proteomics to study gene regulation and tumor cell biology during tumor evolution. We believe that the generation of relevant preclinical models combined with a robust mechanistic understanding of gene regulation in lung cancer will result in the development of hypothesis-driven therapeutic strategies that can be used to effectively treat patients with lung cancer. 

Beyond our work at the bench, we consciously strive to cultivate a supportive lab environment, provide intentional mentorship for each lab member, and have fun while doing science!